Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

Keisuke Mochida, Yu Oikawa, Yayoi Kimura, Hiromi Kirisako, Hisashi Hirano, Yoshinori Ohsumi and Hitoshi Nakatogawa ()
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Keisuke Mochida: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Yu Oikawa: Frontier Research Center, Tokyo Institute of Technology
Yayoi Kimura: Advanced Medical Research Center, Yokohama City University
Hiromi Kirisako: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Hisashi Hirano: Advanced Medical Research Center, Yokohama City University
Yoshinori Ohsumi: Frontier Research Center, Tokyo Institute of Technology
Hitoshi Nakatogawa: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

Nature, 2015, vol. 522, issue 7556, 359-362

Abstract: In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions.

Date: 2015
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DOI: 10.1038/nature14506

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