Activating positive memory engrams suppresses depression-like behaviour

Steve Ramirez, Xu Liu, Christopher J. MacDonald, Anthony Moffa, Joanne Zhou, Roger L. Redondo and Susumu Tonegawa ()
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Steve Ramirez: RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Christopher J. MacDonald: RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Anthony Moffa: RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Joanne Zhou: RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Roger L. Redondo: RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Susumu Tonegawa: RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Nature, 2015, vol. 522, issue 7556, 335-339

Abstract: Acute re-activation of a positive memory engram suppresses depression-like behaviour in mice exposed to chronic stress, mediated by a hippocampus–amygdala–nucleus-accumbens pathway.

Date: 2015
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DOI: 10.1038/nature14514

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