PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

Hsiang-Ying Lee, Xiaofei Gao, M. Inmaculada Barrasa, Hu Li, Russell R. Elmes, Luanne L. Peters and Harvey F. Lodish ()
Additional contact information
Hsiang-Ying Lee: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Xiaofei Gao: Whitehead Institute for Biomedical Research, Nine Cambridge Center
M. Inmaculada Barrasa: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Hu Li: Center for Individualized Medicine, Mayo Clinic
Russell R. Elmes: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Luanne L. Peters: The Jackson Laboratory
Harvey F. Lodish: Whitehead Institute for Biomedical Research, Nine Cambridge Center

Nature, 2015, vol. 522, issue 7557, 474-477

Abstract: Some types of anaemia do not respond to erythropoietin (Epo) treatment because patients do not have sufficient numbers of Epo-sensitive erythroid precursor cells; here, two agonists of PPAR-α are found to synergize with glucocorticoid treatment to promote early erythroid progenitor self-renewal, increasing the production of mature red blood cells in both human and mouse cultures and alleviating anaemia in mouse models.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature14326 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14326

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14326

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().