Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Marina Caskey, Florian Klein, Julio C. C. Lorenzi, Michael S. Seaman, Anthony P. West, Noreen Buckley, Gisela Kremer, Lilian Nogueira, Malte Braunschweig, Johannes F. Scheid, Joshua A. Horwitz, Irina Shimeliovich, Sivan Ben-Avraham, Maggi Witmer-Pack, Martin Platten, Clara Lehmann, Leah A. Burke, Thomas Hawthorne, Robert J. Gorelick, Bruce D. Walker, Tibor Keler, Roy M. Gulick, Gerd Fätkenheuer, Sarah J. Schlesinger and Michel C. Nussenzweig ()
Additional contact information
Marina Caskey: Laboratory of Molecular Immunology, The Rockefeller University
Florian Klein: Laboratory of Molecular Immunology, The Rockefeller University
Julio C. C. Lorenzi: Laboratory of Molecular Immunology, The Rockefeller University
Michael S. Seaman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Anthony P. West: California Institute of Technology
Noreen Buckley: Laboratory of Molecular Immunology, The Rockefeller University
Gisela Kremer: University Hospital of Cologne
Lilian Nogueira: Laboratory of Molecular Immunology, The Rockefeller University
Malte Braunschweig: Laboratory of Molecular Immunology, The Rockefeller University
Johannes F. Scheid: Laboratory of Molecular Immunology, The Rockefeller University
Joshua A. Horwitz: Laboratory of Molecular Immunology, The Rockefeller University
Irina Shimeliovich: Laboratory of Molecular Immunology, The Rockefeller University
Sivan Ben-Avraham: Laboratory of Molecular Immunology, The Rockefeller University
Maggi Witmer-Pack: Laboratory of Molecular Immunology, The Rockefeller University
Martin Platten: University Hospital of Cologne
Clara Lehmann: University Hospital of Cologne
Leah A. Burke: Laboratory of Molecular Immunology, The Rockefeller University
Thomas Hawthorne: Celldex Therapeutics, Inc.
Robert J. Gorelick: AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick, Frederick National Laboratory for Cancer Research
Bruce D. Walker: Ragon Institute of MGH, MIT and Harvard, Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School
Tibor Keler: Celldex Therapeutics, Inc.
Roy M. Gulick: Weill Medical College of Cornell University
Gerd Fätkenheuer: University Hospital of Cologne
Sarah J. Schlesinger: Laboratory of Molecular Immunology, The Rockefeller University
Michel C. Nussenzweig: Laboratory of Molecular Immunology, The Rockefeller University

Nature, 2015, vol. 522, issue 7557, 487-491

Abstract: A phase I study of passive immunization with a CD4 binding-site-directed broadly neutralizing antibody shows that it transiently reduces HIV-1 viral loads in humans.

Date: 2015
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DOI: 10.1038/nature14411

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