Cell death during crisis is mediated by mitotic telomere deprotection

Makoto T. Hayashi, Anthony J. Cesare, Teresa Rivera and Jan Karlseder ()
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Makoto T. Hayashi: The Salk Institute for Biological Studies
Anthony J. Cesare: The Salk Institute for Biological Studies
Teresa Rivera: The Salk Institute for Biological Studies
Jan Karlseder: The Salk Institute for Biological Studies

Nature, 2015, vol. 522, issue 7557, 492-496

Abstract: Cells that bypass senescence in the absence of the p53 tumour suppressor protein have shortened telomeres that undergo fusion, and these fusions trigger mitotic arrest and cell death in crisis.

Date: 2015
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DOI: 10.1038/nature14513

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