Competitive binding of antagonistic peptides fine-tunes stomatal patterning

Jin Suk Lee, Marketa Hnilova, Michal Maes, Ya-Chen Lisa Lin, Aarthi Putarjunan, Soon-Ki Han, Julian Avila and Keiko U. Torii ()
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Jin Suk Lee: Howard Hughes Medical Institute, University of Washington
Marketa Hnilova: University of Washington
Michal Maes: University of Washington
Ya-Chen Lisa Lin: Howard Hughes Medical Institute, University of Washington
Aarthi Putarjunan: University of Washington
Soon-Ki Han: Howard Hughes Medical Institute, University of Washington
Julian Avila: Howard Hughes Medical Institute, University of Washington
Keiko U. Torii: Howard Hughes Medical Institute, University of Washington

Nature, 2015, vol. 522, issue 7557, 439-443

Abstract: Abstract During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalling peptides orchestrate pattern formation at a molecular level remains unclear. Here we report in Arabidopsis that Stomagen (also called EPF-LIKE9) peptide, which promotes stomatal development, requires ERECTA (ER)-family receptor kinases and interferes with the inhibition of stomatal development by the EPIDERMAL PATTERNING FACTOR 2 (EPF2)–ER module. Both EPF2 and Stomagen directly bind to ER and its co-receptor TOO MANY MOUTHS. Stomagen peptide competitively replaced EPF2 binding to ER. Furthermore, application of EPF2, but not Stomagen, elicited rapid phosphorylation of downstream signalling components in vivo. Our findings demonstrate how a plant receptor agonist and antagonist define inhibitory and inductive cues to fine-tune tissue patterning on the plant epidermis.

Date: 2015
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DOI: 10.1038/nature14561

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