Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

María Elena Fernández-Sánchez, Sandrine Barbier, Joanne Whitehead, Gaëlle Béalle, Aude Michel, Heldmuth Latorre-Ossa, Colette Rey, Laura Fouassier, Audrey Claperon, Laura Brullé, Elodie Girard, Nicolas Servant, Thomas Rio-Frio, Hélène Marie, Sylviane Lesieur, Chantal Housset, Jean-Luc Gennisson, Mickaël Tanter, Christine Ménager, Silvia Fre, Sylvie Robine and Emmanuel Farge ()
Additional contact information
María Elena Fernández-Sánchez: Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes
Sandrine Barbier: Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes
Joanne Whitehead: Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes
Gaëlle Béalle: UPMC, Sorbonne Universités, Laboratoire PHENIX Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, CNRS UMR 8234
Aude Michel: UPMC, Sorbonne Universités, Laboratoire PHENIX Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, CNRS UMR 8234
Heldmuth Latorre-Ossa: Langevin Institut, Waves and Images ESPCI ParisTech, PSL Research University, CNRS UMR7587, Inserm U979
Colette Rey: Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine
Laura Fouassier: Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine
Audrey Claperon: Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine
Laura Brullé: CNRS UMR3666/INSERM U1143, Endocytic Trafficking and Therapeutic Delivery, Institut Curie, Centre de Recherche
Elodie Girard: Bioinformatic platform, U900, Institut Curie, MINES ParisTech
Nicolas Servant: Bioinformatic platform, U900, Institut Curie, MINES ParisTech
Thomas Rio-Frio: Next-generation sequencing platform, Institut Curie
Hélène Marie: CNRS UMR 8612, Laboratoire Physico-Chimie des Systèmes Polyphasés, Institut Galien Paris-Sud, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud
Sylviane Lesieur: CNRS UMR 8612, Laboratoire Physico-Chimie des Systèmes Polyphasés, Institut Galien Paris-Sud, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud
Chantal Housset: Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine
Jean-Luc Gennisson: Langevin Institut, Waves and Images ESPCI ParisTech, PSL Research University, CNRS UMR7587, Inserm U979
Mickaël Tanter: Langevin Institut, Waves and Images ESPCI ParisTech, PSL Research University, CNRS UMR7587, Inserm U979
Christine Ménager: UPMC, Sorbonne Universités, Laboratoire PHENIX Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, CNRS UMR 8234
Silvia Fre: CNRS UMR 3215/INSERM U934, Unité de Génétique et Biologie du Développement, Notch Signaling in Stem Cells and Tumors, Institut Curie, Centre de Recherche
Sylvie Robine: CNRS UMR144, Compartimentation et dynamique cellulaires, Morphogenesis and Cell Signalling Institut Curie, Centre de Recherche
Emmanuel Farge: Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes

Nature, 2015, vol. 523, issue 7558, 92-95

Abstract: Magnetically induced mechanical strain mimicking the pressure exerted by a growing tumour in the mouse colon is shown to activate the tumorigenic β-catenin pathway in healthy epithelia, suggesting an alternative pathway, mechanotransductive in nature, in the propagation of tumorigenesis and growth from tumour to healthy tissue.

Date: 2015
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DOI: 10.1038/nature14329

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