Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating

Rosanna P. Baker and Siniša Urban ()
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Rosanna P. Baker: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Siniša Urban: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine

Nature, 2015, vol. 523, issue 7558, 101-105

Abstract: Calcium potently stimulates proteolysis by endogenous rhomboid-4, an intramembrane protease that contains a cytoplasmic calcium-binding EF-hand domain.

Date: 2015
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DOI: 10.1038/nature14357

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