Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

Bradley A. Webb, Farhad Forouhar, Fu-En Szu, Jayaraman Seetharaman, Liang Tong () and Diane L. Barber ()
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Bradley A. Webb: University of California
Farhad Forouhar: Northeast Structural Genomics Consortium, Columbia University
Fu-En Szu: Northeast Structural Genomics Consortium, Columbia University
Jayaraman Seetharaman: Northeast Structural Genomics Consortium, Columbia University
Liang Tong: Northeast Structural Genomics Consortium, Columbia University
Diane L. Barber: University of California

Nature, 2015, vol. 523, issue 7558, 111-114

Abstract: The first structures of the mammalian phosphofructokinase-1 tetramer are reported, for the human platelet isoform, in complex with ATP–Mg2+ and ADP.

Date: 2015
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DOI: 10.1038/nature14405

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