Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour

Mathieu Frechin, Thomas Stoeger, Stephan Daetwyler, Charlotte Gehin, Nico Battich, Eva-Maria Damm, Lilli Stergiou, Howard Riezman and Lucas Pelkmans ()
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Mathieu Frechin: Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich
Thomas Stoeger: Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich
Stephan Daetwyler: Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich
Charlotte Gehin: University of Geneva
Nico Battich: Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich
Eva-Maria Damm: Institute of Molecular Systems Biology, ETH Zurich
Lilli Stergiou: Institute of Molecular Systems Biology, ETH Zurich
Howard Riezman: University of Geneva
Lucas Pelkmans: Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich

Nature, 2015, vol. 523, issue 7558, 88-91

Abstract: Little is known about how individual cells within a group of cells exposed to the same external signals can produce a specific individual response to their local microenvironment; a quantitative analysis of cell crowding reveals that single cells can autonomously sense local crowding though their ability to spread and activate focal adhesion kinase (FAK), which ultimately results in changes in cellular lipid composition.

Date: 2015
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DOI: 10.1038/nature14429

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