Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Stefani Spranger, Riyue Bao and Thomas F. Gajewski ()
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Stefani Spranger: The University of Chicago
Riyue Bao: Center for Research Informatics, The University of Chicago
Thomas F. Gajewski: The University of Chicago

Nature, 2015, vol. 523, issue 7559, 231-235

Abstract: Only a subset of patients with melanoma responds to new immunotherapeutic therapies; here, β-catenin signalling is identified as an important pathway that confers resistance to this type of approach, with implications for future treatment strategies.

Date: 2015
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DOI: 10.1038/nature14404

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