Condensin-driven remodelling of X chromosome topology during dosage compensation

Emily Crane, Qian Bian, Rachel Patton McCord, Bryan R. Lajoie, Bayly S. Wheeler, Edward J. Ralston, Satoru Uzawa, Job Dekker () and Barbara J. Meyer ()
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Emily Crane: University of California-Berkeley
Qian Bian: University of California-Berkeley
Rachel Patton McCord: Program in Systems Biology, University of Massachusetts Medical School
Bryan R. Lajoie: Program in Systems Biology, University of Massachusetts Medical School
Bayly S. Wheeler: University of California-Berkeley
Edward J. Ralston: University of California-Berkeley
Satoru Uzawa: University of California-Berkeley
Job Dekker: Program in Systems Biology, University of Massachusetts Medical School
Barbara J. Meyer: University of California-Berkeley

Nature, 2015, vol. 523, issue 7559, 240-244

Abstract: Genome-wide chromosome conformation capture analysis in C. elegans reveals that the dosage compensation complex, a condensin complex, remodels the X chromosomes of hermaphrodites into a sex-specific topology distinct from autosomes while regulating gene expression chromosome-wide.

Date: 2015
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DOI: 10.1038/nature14450

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