Human body epigenome maps reveal noncanonical DNA methylation variation

Matthew D. Schultz, Yupeng He, John W. Whitaker, Manoj Hariharan, Eran A. Mukamel, Danny Leung, Nisha Rajagopal, Joseph R. Nery, Mark A. Urich, Huaming Chen, Shin Lin, Yiing Lin, Inkyung Jung, Anthony D. Schmitt, Siddarth Selvaraj, Bing Ren, Terrence J. Sejnowski, Wei Wang and Joseph R. Ecker ()
Additional contact information
Matthew D. Schultz: Bioinformatics Program, University of California
Yupeng He: Bioinformatics Program, University of California
John W. Whitaker: University of California
Manoj Hariharan: Genomic Analysis Laboratory, The Salk Institute for Biological Studies
Eran A. Mukamel: Computational Neurobiology Laboratory, The Salk Institute for Biological Studies
Danny Leung: Ludwig Institute for Cancer Research
Nisha Rajagopal: Ludwig Institute for Cancer Research
Joseph R. Nery: Genomic Analysis Laboratory, The Salk Institute for Biological Studies
Mark A. Urich: Genomic Analysis Laboratory, The Salk Institute for Biological Studies
Huaming Chen: Genomic Analysis Laboratory, The Salk Institute for Biological Studies
Shin Lin: Stanford University
Yiing Lin: Washington University School of Medicine
Inkyung Jung: Ludwig Institute for Cancer Research
Anthony D. Schmitt: Ludwig Institute for Cancer Research
Siddarth Selvaraj: Bioinformatics Program, University of California
Bing Ren: Ludwig Institute for Cancer Research
Terrence J. Sejnowski: Computational Neurobiology Laboratory, The Salk Institute for Biological Studies
Wei Wang: University of California
Joseph R. Ecker: Genomic Analysis Laboratory, The Salk Institute for Biological Studies

Nature, 2015, vol. 523, issue 7559, 212-216

Abstract: As part of the Epigenome Roadmap Project, genome-wide maps of DNA methylation and transcriptomes together with genomic DNA sequencing of 18 different primary human tissue types from 4 individuals are presented; analysis reveals widespread differential methylation of CG sites between tissues, and the presence of non-CG methylation in adult tissues.

Date: 2015
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DOI: 10.1038/nature14465

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