Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication

C. Lori, S. Ozaki, S. Steiner, R. Böhm, S. Abel, B. N. Dubey, T. Schirmer, S. Hiller and U. Jenal ()
Additional contact information
C. Lori: Focal area of Infection Biology, Biozentrum, University of Basel
S. Ozaki: Focal area of Infection Biology, Biozentrum, University of Basel
S. Steiner: Focal area of Infection Biology, Biozentrum, University of Basel
R. Böhm: Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel
S. Abel: Focal area of Infection Biology, Biozentrum, University of Basel
B. N. Dubey: Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel
T. Schirmer: Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel
S. Hiller: Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel
U. Jenal: Focal area of Infection Biology, Biozentrum, University of Basel

Nature, 2015, vol. 523, issue 7559, 236-239

Abstract: In Caulobacter crescentus, oscillating levels of the second messenger cyclic-di-GMP drive the cell cycle through regulation of the essential cell cycle kinase CckA; as its levels increase during the G1–S transition, cyclic-di-GMP binds to CckA to inhibit kinase and stimulate phosphatase activity, thereby enabling replication initiation.

Date: 2015
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DOI: 10.1038/nature14473

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