Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

Wataru Kimura, Feng Xiao, Diana C. Canseco, Shalini Muralidhar, SuWannee Thet, Helen M. Zhang, Yezan Abderrahman, Rui Chen, Joseph A. Garcia, John M. Shelton, James A. Richardson, Abdelrahman M. Ashour, Aroumougame Asaithamby, Hanquan Liang, Chao Xing, Zhigang Lu, Cheng Cheng Zhang and Hesham A. Sadek ()
Additional contact information
Wataru Kimura: The University of Texas Southwestern Medical Center
Feng Xiao: The University of Texas Southwestern Medical Center
Diana C. Canseco: The University of Texas Southwestern Medical Center
Shalini Muralidhar: The University of Texas Southwestern Medical Center
SuWannee Thet: The University of Texas Southwestern Medical Center
Helen M. Zhang: The University of Texas Southwestern Medical Center
Yezan Abderrahman: The University of Texas Southwestern Medical Center
Rui Chen: The University of Texas Southwestern Medical Center
Joseph A. Garcia: The University of Texas Southwestern Medical Center
John M. Shelton: The University of Texas Southwestern Medical Center
James A. Richardson: The University of Texas Southwestern Medical Center
Abdelrahman M. Ashour: The University of Texas Southwestern Medical Center
Aroumougame Asaithamby: The University of Texas Southwestern Medical Center
Hanquan Liang: McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center
Chao Xing: McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center
Zhigang Lu: The University of Texas Southwestern Medical Center
Cheng Cheng Zhang: The University of Texas Southwestern Medical Center
Hesham A. Sadek: The University of Texas Southwestern Medical Center

Nature, 2015, vol. 523, issue 7559, 226-230

Abstract: Fate-mapping hypoxic cells in the mouse heart identifies a rare population of cycling cardiomyocytes, which show characteristics of neonatal cardiomyocytes, including smaller size and mononucleation, and contribute to new cardiomyocyte formation in the adult heart.

Date: 2015
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DOI: 10.1038/nature14582

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