Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau (), Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris and Jonathan Kipnis ()
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Antoine Louveau: Center for Brain Immunology and Glia, School of Medicine, University of Virginia
Igor Smirnov: Center for Brain Immunology and Glia, School of Medicine, University of Virginia
Timothy J. Keyes: Center for Brain Immunology and Glia, School of Medicine, University of Virginia
Jacob D. Eccles: Medical Scientist Training Program, School of Medicine, University of Virginia
Sherin J. Rouhani: Medical Scientist Training Program, School of Medicine, University of Virginia
J. David Peske: Medical Scientist Training Program, School of Medicine, University of Virginia
Noel C. Derecki: Center for Brain Immunology and Glia, School of Medicine, University of Virginia
David Castle: School of Medicine, University of Virginia
James W. Mandell: School of Medicine, University of Virginia
Kevin S. Lee: Center for Brain Immunology and Glia, School of Medicine, University of Virginia
Tajie H. Harris: Center for Brain Immunology and Glia, School of Medicine, University of Virginia
Jonathan Kipnis: Center for Brain Immunology and Glia, School of Medicine, University of Virginia

Nature, 2015, vol. 523, issue 7560, 337-341

Abstract: The central nervous system undergoes constant immune surveillance, but the route that immune cells take to exit the brain has been unclear as it had been thought to lack a classical lymphatic drainage system; here functional lymphatic vessels able to carry both fluid and immune cells from the cerebrospinal fluid are shown to be located in the brain meninges.

Date: 2015
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DOI: 10.1038/nature14432

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