HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

Victoria A. Blaho, Sylvain Galvani, Eric Engelbrecht, Catherine Liu, Steven L. Swendeman, Mari Kono, Richard L. Proia, Lawrence Steinman, May H. Han and Timothy Hla ()
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Victoria A. Blaho: Center for Vascular Biology, Weill Medical College of Cornell University
Sylvain Galvani: Center for Vascular Biology, Weill Medical College of Cornell University
Eric Engelbrecht: Center for Vascular Biology, Weill Medical College of Cornell University
Catherine Liu: Center for Vascular Biology, Weill Medical College of Cornell University
Steven L. Swendeman: Center for Vascular Biology, Weill Medical College of Cornell University
Mari Kono: Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Richard L. Proia: Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Lawrence Steinman: Stanford University
May H. Han: Stanford University
Timothy Hla: Center for Vascular Biology, Weill Medical College of Cornell University

Nature, 2015, vol. 523, issue 7560, 342-346

Abstract: Apolipoprotein-M-bound sphingosine-1-phosphate (S1P) is found to restrain the generation of new lymphocytes—and, consequently, adaptive immune responses—by activating the S1P1 receptor on bone marrow lymphocyte progenitors in mice.

Date: 2015
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DOI: 10.1038/nature14462

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