Structural basis for retroviral integration into nucleosomes

Daniel P. Maskell, Ludovic Renault, Erik Serrao, Paul Lesbats, Rishi Matadeen, Stephen Hare, Dirk Lindemann, Alan N. Engelman, Alessandro Costa () and Peter Cherepanov ()
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Daniel P. Maskell: Chromatin Structure and Mobile DNA, The Francis Crick Institute
Ludovic Renault: Architecture and Dynamics of Macromolecular Machines, Clare Hall Laboratories, The Francis Crick Institute
Erik Serrao: Dana-Farber Cancer Institute
Paul Lesbats: Chromatin Structure and Mobile DNA, The Francis Crick Institute
Rishi Matadeen: NeCEN, Gorlaeus Laboratory
Stephen Hare: Imperial College London
Dirk Lindemann: Institute of Virology, Technische Universität Dresden
Alan N. Engelman: Dana-Farber Cancer Institute
Alessandro Costa: Architecture and Dynamics of Macromolecular Machines, Clare Hall Laboratories, The Francis Crick Institute
Peter Cherepanov: Chromatin Structure and Mobile DNA, The Francis Crick Institute

Nature, 2015, vol. 523, issue 7560, 366-369

Abstract: Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process.

Date: 2015
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DOI: 10.1038/nature14495

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