Network evolution hinges on history

Aaron M. New and Ben Lehner ()
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Aaron M. New: Aaron M. New and Ben Lehner are at the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, and at the Universitat Pompeu Fabra, Barcelona, Spain.
Ben Lehner: Aaron M. New and Ben Lehner are at the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, and at the Universitat Pompeu Fabra, Barcelona, Spain.

Nature, 2015, vol. 523, issue 7560, 297-298

Abstract: The effects of mutations in proteins can depend on the occurrence of previous mutations. It emerges that such historical contingency is also important during the evolution of gene regulatory networks. See Letter p.361

Date: 2015
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DOI: 10.1038/nature14537

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