A noisy linear map underlies oscillations in cell size and gene expression in bacteria

Yu Tanouchi, Anand Pai, Heungwon Park, Shuqiang Huang, Rumen Stamatov, Nicolas E. Buchler and Lingchong You ()
Additional contact information
Yu Tanouchi: Duke University
Anand Pai: Duke University
Heungwon Park: Duke University
Shuqiang Huang: Duke University
Rumen Stamatov: Computational Biology and Bioinformatics, Duke University
Nicolas E. Buchler: Duke University
Lingchong You: Duke University

Nature, 2015, vol. 523, issue 7560, 357-360

Abstract: Quantification of single-cell growth over long periods of time in E. coli shows transient oscillations in cell size, with periods stretching across more than ten generations; a noisy negative feedback on cell-size control is proposed in which cells with a small initial size tend to divide later than cells with a large initial size with implications for the genetic and physiological processes required.

Date: 2015
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DOI: 10.1038/nature14562

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