Intersecting transcription networks constrain gene regulatory evolution

Trevor R. Sorrells, Lauren N. Booth, Brian B. Tuch and Alexander D. Johnson ()
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Trevor R. Sorrells: University of California
Lauren N. Booth: University of California
Brian B. Tuch: University of California
Alexander D. Johnson: University of California

Nature, 2015, vol. 523, issue 7560, 361-365

Abstract: Epistatic interactions, whereby a mutation's effect is contingent on another mutation, have been shown to constrain evolution within single proteins, and how such interactions arise in gene regulatory networks has remained unclear; here the appearance of pheromone-response regulator binding sites in the regulatory DNA of the a-specific genes of Saccharomyces cerevisiae are shown to have required specific changes in a second pathway during the evolution from its common ancestor with Candida albicans.

Date: 2015
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DOI: 10.1038/nature14613

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