Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment

Pulin Li, Jamie L. Lahvic, Vera Binder, Emily K. Pugach, Elizabeth B. Riley, Owen J. Tamplin, Dipak Panigrahy, Teresa V. Bowman, Francesca G. Barrett, Garrett C. Heffner, Shannon McKinney-Freeman, Thorsten M. Schlaeger, George Q. Daley, Darryl C. Zeldin and Leonard I. Zon ()
Additional contact information
Pulin Li: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Jamie L. Lahvic: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Vera Binder: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Emily K. Pugach: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Elizabeth B. Riley: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Owen J. Tamplin: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Dipak Panigrahy: Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Teresa V. Bowman: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Francesca G. Barrett: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Garrett C. Heffner: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Shannon McKinney-Freeman: St Jude Children's Research Hospital
Thorsten M. Schlaeger: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
George Q. Daley: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
Darryl C. Zeldin: National Institute of Environmental Health Sciences, National Institutes of Health
Leonard I. Zon: Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School

Nature, 2015, vol. 523, issue 7561, 468-471

Abstract: An in vivo imaging-based competitive transplant screen in zebrafish identifies epoxyeicosatrienoic acids as enhancers of haematopoietic stem and progenitor cell (HSPC) engraftment; these derivatives of arachidonic acid also promote zebrafish developmental HSPC specification through a PI(3)K-dependent AP-1 and runx1 transcriptional program and their pro-engraftment effect is conserved in mammals (indicating clinical potential).

Date: 2015
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DOI: 10.1038/nature14569

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