Directional dominance on stature and cognition in diverse human populations

Peter K. Joshi, Tonu Esko, Hannele Mattsson, Niina Eklund, Ilaria Gandin, Teresa Nutile, Anne U. Jackson, Claudia Schurmann, Albert V. Smith, Weihua Zhang, Yukinori Okada, Alena Stančáková, Jessica D. Faul, Wei Zhao, Traci M. Bartz, Maria Pina Concas, Nora Franceschini, Stefan Enroth, Veronique Vitart, Stella Trompet, Xiuqing Guo, Daniel I. Chasman, Jeffrey R. O'Connel, Tanguy Corre, Suraj S. Nongmaithem, Yuning Chen, Massimo Mangino, Daniela Ruggiero, Michela Traglia, Aliki-Eleni Farmaki, Tim Kacprowski, Andrew Bjonnes, Ashley van der Spek, Ying Wu, Anil K. Giri, Lisa R. Yanek, Lihua Wang, Edith Hofer, Cornelius A. Rietveld, Olga McLeod, Marilyn C. Cornelis, Cristian Pattaro, Niek Verweij, Clemens Baumbach, Abdel Abdellaoui, Helen R. Warren, Dragana Vuckovic, Hao Mei, Claude Bouchard, John R. B. Perry, Stefania Cappellani, Saira S. Mirza, Miles C. Benton, Ulrich Broeckel, Sarah E. Medland, Penelope A. Lind, Giovanni Malerba, Alexander Drong, Loic Yengo, Lawrence F. Bielak, Degui Zhi, Peter J. van der Most, Daniel Shriner, Reedik Mägi, Gibran Hemani, Tugce Karaderi, Zhaoming Wang, Tian Liu, Ilja Demuth, Jing Hua Zhao, Weihua Meng, Lazaros Lataniotis, Sander W. van der Laan, Jonathan P. Bradfield, Andrew R. Wood, Amelie Bonnefond, Tarunveer S. Ahluwalia, Leanne M. Hall, Erika Salvi, Seyhan Yazar, Lisbeth Carstensen, Hugoline G. de Haan, Mark Abney, Uzma Afzal, Matthew A. Allison, Najaf Amin, Folkert W. Asselbergs, Stephan J. L. Bakker, R. Graham Barr, Sebastian E. Baumeister, Daniel J. Benjamin, Sven Bergmann, Eric Boerwinkle, Erwin P. Bottinger, Archie Campbell, Aravinda Chakravarti, Yingleong Chan, Stephen J. Chanock, Constance Chen, Y.-D. Ida Chen, Francis S. Collins, John Connell, Adolfo Correa, L. Adrienne Cupples, George Davey Smith, Gail Davies, Marcus Dörr, Georg Ehret, Stephen B. Ellis, Bjarke Feenstra, Mary F. Feitosa, Ian Ford, Caroline S. Fox, Timothy M. Frayling, Nele Friedrich, Frank Geller, Generation Scotland, Irina Gillham-Nasenya, Omri Gottesman, Misa Graff, Francine Grodstein, Charles Gu, Chris Haley, Christopher J. Hammond, Sarah E. Harris, Tamara B. Harris, Nicholas D. Hastie, Nancy L. Heard-Costa, Kauko Heikkilä, Lynne J. Hocking, Georg Homuth, Jouke-Jan Hottenga, Jinyan Huang, Jennifer E. Huffman, Pirro G. Hysi, M. Arfan Ikram, Erik Ingelsson, Anni Joensuu, Åsa Johansson, Pekka Jousilahti, J. Wouter Jukema, Mika Kähönen, Yoichiro Kamatani, Stavroula Kanoni, Shona M. Kerr, Nazir M. Khan, Philipp Koellinger, Heikki A. Koistinen, Manraj K. Kooner, Michiaki Kubo, Johanna Kuusisto, Jari Lahti, Lenore J. Launer, Rodney A. Lea, Benjamin Lehne, Terho Lehtimäki, David C.M. Liewald, Lars Lind, Marie Loh, Marja-Liisa Lokki, Stephanie J. London, Stephanie J. Loomis, Anu Loukola, Yingchang Lu, Thomas Lumley, Annamari Lundqvist, Satu Männistö, Pedro Marques-Vidal, Corrado Masciullo, Angela Matchan, Rasika A. Mathias, Koichi Matsuda, James B. Meigs, Christa Meisinger, Thomas Meitinger, Cristina Menni, Frank D. Mentch, Evelin Mihailov, Lili Milani, May E. Montasser, Grant W. Montgomery, Alanna Morrison, Richard H. Myers, Rajiv Nadukuru, Pau Navarro, Mari Nelis, Markku S. Nieminen, Ilja M. Nolte, George T. O'Connor, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R. Palmas, James S. Pankow, Inga Patarcic, Francesca Pavani, Patricia A. Peyser, Kirsi Pietilainen, Neil Poulter, Inga Prokopenko, Sarju Ralhan, Paul Redmond, Stephen S. Rich, Harri Rissanen, Antonietta Robino, Lynda M. Rose, Richard Rose, Cinzia Sala, Babatunde Salako, Veikko Salomaa, Antti-Pekka Sarin, Richa Saxena, Helena Schmidt, Laura J. Scott, William R. Scott, Bengt Sennblad, Sudha Seshadri, Peter Sever, Smeeta Shrestha, Blair H. Smith, Jennifer A. Smith, Nicole Soranzo, Nona Sotoodehnia, Lorraine Southam, Alice V. Stanton, Maria G. Stathopoulou, Konstantin Strauch, Rona J. Strawbridge, Matthew J. Suderman, Nikhil Tandon, Sian-Tsun Tang, Kent D. Taylor, Bamidele O. Tayo, Anna Maria Töglhofer, Maciej Tomaszewski, Natalia Tšernikova, Jaakko Tuomilehto, Andre G. Uitterlinden, Dhananjay Vaidya, Astrid van Hylckama Vlieg, Jessica van Setten, Tuula Vasankari, Sailaja Vedantam, Efthymia Vlachopoulou, Diego Vozzi, Eero Vuoksimaa, Melanie Waldenberger, Erin B. Ware, William Wentworth-Shields, John B. Whitfield, Sarah Wild, Gonneke Willemsen, Chittaranjan S. Yajnik, Jie Yao, Gianluigi Zaza, Xiaofeng Zhu, Rany M. Salem, Mads Melbye, Hans Bisgaard, Nilesh J. Samani, Daniele Cusi, David A. Mackey, Richard S. Cooper, Philippe Froguel, Gerard Pasterkamp, Struan F.A. Grant, Hakon Hakonarson, Luigi Ferrucci, Robert A. Scott, Andrew D. Morris, Colin N. A. Palmer, George Dedoussis, Panos Deloukas, Lars Bertram, Ulman Lindenberger, Sonja I. Berndt, Cecilia M. Lindgren, Nicholas J. Timpson, Anke Tönjes, Patricia B. Munroe, Thorkild I. A. Sørensen, Charles N. Rotimi, Donna K. Arnett, Albertine J. Oldehinkel, Sharon L. R. Kardia, Beverley Balkau, Giovanni Gambaro, Andrew P. Morris, Johan G. Eriksson, Margie J. Wright, Nicholas G. Martin, Steven C. Hunt, John M. Starr, Ian J. Deary, Lyn R. Griffiths, Henning Tiemeier, Nicola Pirastu, Jaakko Kaprio, Nicholas J. Wareham, Louis Pérusse, James G. Wilson, Giorgia Girotto, Mark J. Caulfield, Olli Raitakari, Dorret I. Boomsma, Christian Gieger, Pim van der Harst, Andrew A. Hicks, Peter Kraft, Juha Sinisalo, Paul Knekt, Magnus Johannesson, Patrik K. E. Magnusson, Anders Hamsten, Reinhold Schmidt, Ingrid B. Borecki, Erkki Vartiainen, Diane M. Becker, Dwaipayan Bharadwaj, Karen L. Mohlke, Michael Boehnke, Cornelia M. van Duijn, Dharambir K. Sanghera, Alexander Teumer, Eleftheria Zeggini, Andres Metspalu, Paolo Gasparini, Sheila Ulivi, Carole Ober, Daniela Toniolo, Igor Rudan, David J. Porteous, Marina Ciullo, Tim D. Spector, Caroline Hayward, Josée Dupuis, Ruth J. F. Loos, Alan F. Wright, Giriraj R. Chandak, Peter Vollenweider, Alan R. Shuldiner, Paul M. Ridker, Jerome I. Rotter, Naveed Sattar, Ulf Gyllensten, Kari E. North, Mario Pirastu, Bruce M. Psaty, David R. Weir, Markku Laakso, Vilmundur Gudnason, Atsushi Takahashi, John C. Chambers, Jaspal S. Kooner, David P. Strachan, Harry Campbell, Joel N. Hirschhorn, Markus Perola, Ozren Polašek and James F. Wilson ()
Additional contact information
Peter K. Joshi: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Tonu Esko: Estonian Genome Center, University of Tartu
Hannele Mattsson: Unit of Public Health Genomics, National Institute for Health and Welfare
Niina Eklund: Unit of Public Health Genomics, National Institute for Health and Welfare
Ilaria Gandin: University of Trieste
Teresa Nutile: Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR
Anne U. Jackson: University of Michigan
Claudia Schurmann: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Albert V. Smith: Icelandic Heart Association
Weihua Zhang: Imperial College London
Yukinori Okada: Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Alena Stančáková: University of Eastern Finland
Jessica D. Faul: Institute for Social Research, University of Michigan
Wei Zhao: University of Michigan
Traci M. Bartz: Cardiovascular Health Research Unit, University of Washington
Maria Pina Concas: Institute of Population Genetics, National Research Council
Nora Franceschini: Epidemiology, University of North Carolina
Stefan Enroth: Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
Veronique Vitart: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Stella Trompet: Leiden University Medical Center
Xiuqing Guo: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
Daniel I. Chasman: Brigham and Women's Hospital
Jeffrey R. O'Connel: Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, University of Maryland School of Medicine
Tanguy Corre: University of Lausanne
Suraj S. Nongmaithem: Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda
Yuning Chen: Boston University School of Public Health
Massimo Mangino: King's College London
Daniela Ruggiero: Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR
Michela Traglia: San Raffaele Scientific Institute
Aliki-Eleni Farmaki: Harokopio University of Athens
Tim Kacprowski: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Andrew Bjonnes: Center for Human Genetic Research
Ashley van der Spek: Erasmus Medical Center
Ying Wu: University of North Carolina
Anil K. Giri: Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology
Lisa R. Yanek: The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
Lihua Wang: Washington University School of Medicine
Edith Hofer: Medical University Graz
Cornelius A. Rietveld: Erasmus School of Economics, Erasmus University Rotterdam
Olga McLeod: Atherosclerosis Research Unit, Karolinska Institutet
Marilyn C. Cornelis: Brigham & Women's Hospital
Cristian Pattaro: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).
Niek Verweij: University of Groningen, University Medical Center Groningen
Clemens Baumbach: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Abdel Abdellaoui: VU University Amsterdam
Helen R. Warren: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Dragana Vuckovic: University of Trieste
Hao Mei: University of Mississippi Medical Center
Claude Bouchard: Pennington Biomedical Research Center
John R. B. Perry: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
Stefania Cappellani: Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
Saira S. Mirza: Erasmus Medical Center
Miles C. Benton: Institute of Health and Biomedical Innovation, Queensland University of Technology
Ulrich Broeckel: Medical College of Wisconsin
Sarah E. Medland: Quantitative Genetics, QIMR Berghofer Medical Research Institute
Penelope A. Lind: Quantitative Genetics, QIMR Berghofer Medical Research Institute
Giovanni Malerba: University of Verona
Alexander Drong: Wellcome Trust Centre for Human Genetics, University of Oxford
Loic Yengo: CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University
Lawrence F. Bielak: University of Michigan
Degui Zhi: University of Alabama at Birmingham
Peter J. van der Most: University of Groningen, University Medical Center Groningen, Groningen
Daniel Shriner: Center for Research on Genomics and Global Health, National Human Genome Research Institute
Reedik Mägi: Estonian Genome Center, University of Tartu
Gibran Hemani: MRC Integrative Epidemiology Unit, University of Bristol
Tugce Karaderi: Wellcome Trust Centre for Human Genetics, University of Oxford
Zhaoming Wang: National Cancer Institute, National Institutes of Health
Tian Liu: Center for Lifespan Psychology, Max Planck Institute for Human Development
Ilja Demuth: Charité Research Group on Geriatrics, Charité – Universitätsmedizin Berlin
Jing Hua Zhao: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
Weihua Meng: Medical Research Institute, University of Dundee
Lazaros Lataniotis: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Sander W. van der Laan: Experimental Cardiology, University Medical Center Utrecht
Jonathan P. Bradfield: Center for Applied Genomics, Children's Hospital of Philadelphia
Andrew R. Wood: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
Amelie Bonnefond: CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University
Tarunveer S. Ahluwalia: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
Leanne M. Hall: University of Leicester, BHF Cardiovascular Research Centre
Erika Salvi: University of Milan
Seyhan Yazar: Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute
Lisbeth Carstensen: Statens Serum Institut
Hugoline G. de Haan: Clinical Epidemiology, Leiden University Medical Center
Mark Abney: University of Chicago
Uzma Afzal: Imperial College London
Matthew A. Allison: University of California San Diego
Najaf Amin: Erasmus Medical Center
Folkert W. Asselbergs: University Medical Center Utrecht
Stephan J. L. Bakker: University of Groningen, University Medical Center Groningen
R. Graham Barr: Columbia University
Sebastian E. Baumeister: Institute for Community Medicine, University Medicine Greifswald
Daniel J. Benjamin: Cornell University
Sven Bergmann: University of Lausanne
Eric Boerwinkle: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston
Erwin P. Bottinger: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Archie Campbell: Centre for Genomic and Experimental Medicine, University of Edinburgh
Aravinda Chakravarti: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Yingleong Chan: Boston Children's Hospital
Stephen J. Chanock: National Cancer Institute, National Institutes of Health
Constance Chen: Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
Y.-D. Ida Chen: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
Francis S. Collins: Genome Technology Branch, National Human Genome Research Institute, NIH
John Connell: College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School
Adolfo Correa: University of Mississippi Medical Center
L. Adrienne Cupples: Boston University School of Public Health
George Davey Smith: MRC Integrative Epidemiology Unit, University of Bristol
Gail Davies: Psychology, University of Edinburgh
Marcus Dörr: University Medicine Greifswald
Georg Ehret: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Stephen B. Ellis: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Bjarke Feenstra: Statens Serum Institut
Mary F. Feitosa: Washington University School of Medicine
Ian Ford: Robertson Centre, University of Glasgow
Caroline S. Fox: National Heart, Lung, and Blood Institute's Framingham Heart Study
Timothy M. Frayling: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
Nele Friedrich: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
Frank Geller: Statens Serum Institut
Generation Scotland: Centre for Genomic and Experimental Medicine, University of Edinburgh
Irina Gillham-Nasenya: King's College London
Omri Gottesman: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Misa Graff: Epidemiology, University of North Carolina
Francine Grodstein: Nutrition, Harvard School of Public Health
Charles Gu: Washington University
Chris Haley: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Christopher J. Hammond: King's College London
Sarah E. Harris: Centre for Genomic and Experimental Medicine, University of Edinburgh
Tamara B. Harris: National Institutes on Aging, National Institutes of Health
Nicholas D. Hastie: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Nancy L. Heard-Costa: National Heart, Lung, and Blood Institute's Framingham Heart Study
Kauko Heikkilä: University of Helsinki, Hjelt Institute
Lynne J. Hocking: Musculoskeletal Research Programme, University of Aberdeen
Georg Homuth: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Jouke-Jan Hottenga: VU University Amsterdam
Jinyan Huang: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine
Jennifer E. Huffman: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Pirro G. Hysi: King's College London
M. Arfan Ikram: Erasmus Medical Center
Erik Ingelsson: Wellcome Trust Centre for Human Genetics, University of Oxford
Anni Joensuu: Unit of Public Health Genomics, National Institute for Health and Welfare
Åsa Johansson: Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
Pekka Jousilahti: National Institute for Health and Welfare
J. Wouter Jukema: Leiden University Medical Center
Mika Kähönen: University of Tampere and Tampere University Hospital
Yoichiro Kamatani: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Stavroula Kanoni: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Shona M. Kerr: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Nazir M. Khan: Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology
Philipp Koellinger: Erasmus School of Economics, Erasmus University Rotterdam
Heikki A. Koistinen: Diabetes Prevention Unit, National Institute for Health and Welfare
Manraj K. Kooner: Ealing Hospital NHS Trust
Michiaki Kubo: Laboratory for Genotyping Development RCfIMS
Johanna Kuusisto: University of Eastern Finland and Kuopio University Hospital
Jari Lahti: Institute of Behavioural Sciences, University of Helsinki
Lenore J. Launer: National Institutes on Aging, National Institutes of Health
Rodney A. Lea: Institute of Health and Biomedical Innovation, Queensland University of Technology
Benjamin Lehne: Imperial College London
Terho Lehtimäki: Fimlab Laboratories and School of Medicine University of Tampere
David C.M. Liewald: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
Lars Lind: University Hospital
Marie Loh: Imperial College London
Marja-Liisa Lokki: Transplantation laboratory, Haartman Institute, University of Helsinki
Stephanie J. London: National Institute of Environmental Health Sciences, National Institutes of Health
Stephanie J. Loomis: Ophthalmology, Massachusetts Eye and Ear
Anu Loukola: University of Helsinki, Hjelt Institute
Yingchang Lu: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Thomas Lumley: University of Auckland
Annamari Lundqvist: Functional Capacity and Welfare, National Institute for Health and Welfare
Satu Männistö: National Institute for Health and Welfare
Pedro Marques-Vidal: University Hospital
Corrado Masciullo: San Raffaele Scientific Institute
Angela Matchan: Human Genetics, Wellcome Trust Sanger Institute, Hinxton
Rasika A. Mathias: The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
Koichi Matsuda: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo
James B. Meigs: Massachusetts General Hospital
Christa Meisinger: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
Thomas Meitinger: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
Cristina Menni: King's College London
Frank D. Mentch: Center for Applied Genomics, Children's Hospital of Philadelphia
Evelin Mihailov: Estonian Genome Center, University of Tartu
Lili Milani: Estonian Genome Center, University of Tartu
May E. Montasser: Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, University of Maryland School of Medicine
Grant W. Montgomery: Molecular Epidemiology, QIMR Berghofer Medical Research Institute
Alanna Morrison: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston
Richard H. Myers: Genome Science Institute, Boston University School of Medicine
Rajiv Nadukuru: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Pau Navarro: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Mari Nelis: Estonian Genome Center, University of Tartu
Markku S. Nieminen: HUCH Heart and Lung center, Helsinki University Central Hospital
Ilja M. Nolte: University of Groningen, University Medical Center Groningen, Groningen
George T. O'Connor: National Heart, Lung, and Blood Institute's Framingham Heart Study
Adesola Ogunniyi: University of Ibadan
Sandosh Padmanabhan: ICAMS, University of Glasgow
Walter R. Palmas: Columbia University
James S. Pankow: University of Minnesota
Inga Patarcic: School of Medicine, University of Split
Francesca Pavani: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).
Patricia A. Peyser: University of Michigan
Kirsi Pietilainen: Institute for Molecular Medicine Finland (FIMM), University of Helsinki
Neil Poulter: International Centre for Circulatory Health, Imperial College London
Inga Prokopenko: School of Public Health, Imperial College London
Sarju Ralhan: Department of Cardiology and Cardio thoracic Surgery Hero DMC Heart Institute
Paul Redmond: Psychology, University of Edinburgh
Stephen S. Rich: University of Virginia School of Medicine
Harri Rissanen: Functional Capacity and Welfare, National Institute for Health and Welfare
Antonietta Robino: Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
Lynda M. Rose: Brigham and Women's Hospital
Richard Rose: Indiana University Bloomington
Cinzia Sala: San Raffaele Scientific Institute
Babatunde Salako: University of Ibadan
Veikko Salomaa: National Institute for Health and Welfare
Antti-Pekka Sarin: Unit of Public Health Genomics, National Institute for Health and Welfare
Richa Saxena: Center for Human Genetic Research
Helena Schmidt: Institute of Molecular Biology and Biochemistry, Medical University Graz
Laura J. Scott: University of Michigan
William R. Scott: Imperial College London
Bengt Sennblad: Atherosclerosis Research Unit, Karolinska Institutet
Sudha Seshadri: National Heart, Lung, and Blood Institute's Framingham Heart Study
Peter Sever: International Centre for Circulatory Health, Imperial College London
Smeeta Shrestha: Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda
Blair H. Smith: University of Dundee
Jennifer A. Smith: University of Michigan
Nicole Soranzo: Human Genetics, Wellcome Trust Sanger Institute, Hinxton
Nona Sotoodehnia: Cardiovascular Health Research Unit, University of Washington
Lorraine Southam: Wellcome Trust Centre for Human Genetics, University of Oxford
Alice V. Stanton: Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green
Maria G. Stathopoulou: UMR INSERM U1122
Konstantin Strauch: Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Rona J. Strawbridge: Atherosclerosis Research Unit, Karolinska Institutet
Matthew J. Suderman: MRC Integrative Epidemiology Unit, University of Bristol
Nikhil Tandon: All India Institute of Medical Sciences
Sian-Tsun Tang: National Heart and Lung Institute, Imperial College London
Kent D. Taylor: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
Bamidele O. Tayo: Stritch School of Medicine, Loyola University Chicago
Anna Maria Töglhofer: Institute of Molecular Biology and Biochemistry, Medical University Graz
Maciej Tomaszewski: University of Leicester, BHF Cardiovascular Research Centre
Natalia Tšernikova: Estonian Genome Center, University of Tartu
Jaakko Tuomilehto: Diabetes Prevention Unit, National Institute for Health and Welfare
Andre G. Uitterlinden: Erasmus Medical Center
Dhananjay Vaidya: The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
Astrid van Hylckama Vlieg: Clinical Epidemiology, Leiden University Medical Center
Jessica van Setten: Experimental Cardiology, University Medical Center Utrecht
Tuula Vasankari: Finnish Lung Health Association
Sailaja Vedantam: Boston Children's Hospital
Efthymia Vlachopoulou: Transplantation laboratory, Haartman Institute, University of Helsinki
Diego Vozzi: Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
Eero Vuoksimaa: University of Helsinki, Hjelt Institute
Melanie Waldenberger: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Erin B. Ware: University of Michigan
William Wentworth-Shields: University of Chicago
John B. Whitfield: Genetic Epidemiology, QIMR Berghofer Medical Research Institute
Sarah Wild: Centre for Population Health Sciences, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Gonneke Willemsen: VU University Amsterdam
Chittaranjan S. Yajnik: Diabetes Unit, KEM Hospital and Research Centre, Rasta Peth, Pune, 411011, India.
Jie Yao: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
Gianluigi Zaza: Renal Unit, University of Verona
Xiaofeng Zhu: Case Western Reserve University
Rany M. Salem: Boston Children's Hospital
Mads Melbye: Statens Serum Institut
Hans Bisgaard: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
Nilesh J. Samani: University of Leicester, BHF Cardiovascular Research Centre
Daniele Cusi: University of Milan
David A. Mackey: Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute
Richard S. Cooper: Stritch School of Medicine, Loyola University Chicago
Philippe Froguel: CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University
Gerard Pasterkamp: Experimental Cardiology, University Medical Center Utrecht
Struan F.A. Grant: Center for Applied Genomics, Children's Hospital of Philadelphia
Hakon Hakonarson: Center for Applied Genomics, Children's Hospital of Philadelphia
Luigi Ferrucci: Translational Gerontology Branch, National institute on Aging
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
Andrew D. Morris: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Colin N. A. Palmer: Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, University of Dundee, Ninewells Hospital and School of Medicine
George Dedoussis: Harokopio University of Athens
Panos Deloukas: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Lars Bertram: Vertebrate Genomics, Max Planck Institute for Molecular Genetics
Ulman Lindenberger: Center for Lifespan Psychology, Max Planck Institute for Human Development
Sonja I. Berndt: National Cancer Institute, National Institutes of Health
Cecilia M. Lindgren: Program in Medical and Population Genetics, Broad Institute
Nicholas J. Timpson: MRC Integrative Epidemiology Unit, University of Bristol
Anke Tönjes: University of Leipzig
Patricia B. Munroe: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Thorkild I. A. Sørensen: MRC Integrative Epidemiology Unit, University of Bristol
Charles N. Rotimi: Center for Research on Genomics and Global Health, National Human Genome Research Institute
Donna K. Arnett: University of Alabama at Birmingham
Albertine J. Oldehinkel: University Medical Center Groningen, University of Groningen
Sharon L. R. Kardia: University of Michigan
Beverley Balkau: Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, Inserm, CESP Center for Research in Epidemiology and Population Health U1018
Giovanni Gambaro: Catholic University of the Sacred Heart
Andrew P. Morris: Estonian Genome Center, University of Tartu
Johan G. Eriksson: National Institute for Health and Welfare
Margie J. Wright: Neuro-Imaging Genetics, QIMR Berghofer Medical Research Institute
Nicholas G. Martin: Genetic Epidemiology, QIMR Berghofer Medical Research Institute
Steven C. Hunt: University of Utah
John M. Starr: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
Ian J. Deary: Psychology, University of Edinburgh
Lyn R. Griffiths: Institute of Health and Biomedical Innovation, Queensland University of Technology
Henning Tiemeier: Erasmus Medical Center
Nicola Pirastu: University of Trieste
Jaakko Kaprio: Institute for Molecular Medicine Finland (FIMM), University of Helsinki
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
Louis Pérusse: Laval University
James G. Wilson: University of Mississippi Medical Center
Giorgia Girotto: University of Trieste
Mark J. Caulfield: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Olli Raitakari: University of Turku and Turku University Hospital
Dorret I. Boomsma: VU University Amsterdam
Christian Gieger: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Pim van der Harst: University of Groningen, University Medical Center Groningen
Andrew A. Hicks: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).
Peter Kraft: Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
Juha Sinisalo: HUCH Heart and Lung center, Helsinki University Central Hospital
Paul Knekt: Functional Capacity and Welfare, National Institute for Health and Welfare
Patrik K. E. Magnusson: Karolinska Institutet
Anders Hamsten: Atherosclerosis Research Unit, Karolinska Institutet
Reinhold Schmidt: Medical University Graz
Ingrid B. Borecki: Washington University School of Medicine
Erkki Vartiainen: National Institute for Health and Welfare
Diane M. Becker: The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
Dwaipayan Bharadwaj: Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology
Karen L. Mohlke: University of North Carolina
Michael Boehnke: University of Michigan
Cornelia M. van Duijn: Erasmus Medical Center
Dharambir K. Sanghera: University of Oklahoma Health Sciences Center
Alexander Teumer: Institute for Community Medicine, University Medicine Greifswald
Eleftheria Zeggini: Human Genetics, Wellcome Trust Sanger Institute, Hinxton
Andres Metspalu: Estonian Genome Center, University of Tartu
Paolo Gasparini: Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
Sheila Ulivi: Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
Carole Ober: University of Chicago
Daniela Toniolo: San Raffaele Scientific Institute
Igor Rudan: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
David J. Porteous: Centre for Genomic and Experimental Medicine, University of Edinburgh
Marina Ciullo: Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR
Tim D. Spector: King's College London
Caroline Hayward: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Josée Dupuis: Boston University School of Public Health
Ruth J. F. Loos: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Alan F. Wright: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Giriraj R. Chandak: Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda
Peter Vollenweider: University Hospital
Alan R. Shuldiner: Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, University of Maryland School of Medicine
Paul M. Ridker: Brigham and Women's Hospital
Jerome I. Rotter: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
Naveed Sattar: BHF Glasgow Cardiovascular Research Centre, University of Glasgow
Ulf Gyllensten: Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
Kari E. North: Epidemiology, University of North Carolina
Mario Pirastu: Institute of Population Genetics, National Research Council
Bruce M. Psaty: Cardiovascular Health Research Unit, Epidemiology and Health Services, University of Washington
David R. Weir: Institute for Social Research, University of Michigan
Markku Laakso: University of Eastern Finland and Kuopio University Hospital
Vilmundur Gudnason: Icelandic Heart Association
Atsushi Takahashi: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
John C. Chambers: Imperial College London
Jaspal S. Kooner: Ealing Hospital NHS Trust
David P. Strachan: Population Health Research Institute, St George's, University of London, Cranmer Terrace
Harry Campbell: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Joel N. Hirschhorn: Boston Children's Hospital
Markus Perola: Estonian Genome Center, University of Tartu
Ozren Polašek: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
James F. Wilson: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh

Nature, 2015, vol. 523, issue 7561, 459-462

Abstract: An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.

Date: 2015
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DOI: 10.1038/nature14618

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