Parent–progeny sequencing indicates higher mutation rates in heterozygotes

Sihai Yang, Long Wang, Ju Huang, Xiaohui Zhang, Yang Yuan, Jian-Qun Chen, Laurence D. Hurst () and Dacheng Tian ()
Additional contact information
Sihai Yang: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Long Wang: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Ju Huang: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Xiaohui Zhang: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Yang Yuan: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Jian-Qun Chen: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Laurence D. Hurst: The Milner Centre for Evolution, University of Bath
Dacheng Tian: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University

Nature, 2015, vol. 523, issue 7561, 463-467

Abstract: Mutation rates vary within genomes; here, by calling mutation events directly using a parent–offspring sequencing strategy in Arabidopsis, replicated in the rice and honey bee genomes, mutation rates are found to be higher in heterozygotes and in proximity to crossover events.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature14649 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:523:y:2015:i:7561:d:10.1038_nature14649

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14649

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().