Impermanence of dendritic spines in live adult CA1 hippocampus

Alessio Attardo, James E. Fitzgerald and Mark J. Schnitzer ()
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Alessio Attardo: James H. Clark Center for Biomedical Engineering & Sciences, Stanford University
James E. Fitzgerald: James H. Clark Center for Biomedical Engineering & Sciences, Stanford University
Mark J. Schnitzer: James H. Clark Center for Biomedical Engineering & Sciences, Stanford University

Nature, 2015, vol. 523, issue 7562, 592-596

Abstract: A new microendoscopic method reveals that hippocampal dendritic spines in the CA1 region undergo a complete turnover in less than six weeks in adult mice; this contrasts with the much greater stability of synapses in the neocortex and provides a physical basis for the fact that episodic memories are only retained by the mouse hippocampus for a few weeks.

Date: 2015
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DOI: 10.1038/nature14467

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