T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
Eoin F. McKinney (),
James C. Lee,
David R. W. Jayne,
Paul A. Lyons and
Kenneth G. C. Smith ()
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Eoin F. McKinney: University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
James C. Lee: University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
David R. W. Jayne: University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
Paul A. Lyons: University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
Kenneth G. C. Smith: University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
Nature, 2015, vol. 523, issue 7562, 612-616
Abstract:
CD8 T-cell exhaustion, although a negative prognostic indicator during persistent infections, is shown to be associated with a good outcome in autoimmune and inflammatory diseases.
Date: 2015
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DOI: 10.1038/nature14468
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