Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

Lanfeng Wang, Yu Zhou, Liang Xu, Rui Xiao, Xingyu Lu, Liang Chen, Jenny Chong, Hairi Li, Chuan He, Xiang-Dong Fu () and Dong Wang ()
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Lanfeng Wang: Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego
Yu Zhou: School of Medicine, The University of California, San Diego
Liang Xu: Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego
Rui Xiao: School of Medicine, The University of California, San Diego
Xingyu Lu: and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Liang Chen: School of Medicine, The University of California, San Diego
Jenny Chong: Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego
Hairi Li: School of Medicine, The University of California, San Diego
Chuan He: and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Xiang-Dong Fu: School of Medicine, The University of California, San Diego
Dong Wang: Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego

Nature, 2015, vol. 523, issue 7562, 621-625

Abstract: Structural and biochemical studies of RNA polymerase II (Pol II) assembled on DNA containing 5-carboxycytosine reveals that Pol II can sense the oxidized methylation state of DNA and transiently slows down during transcription.

Date: 2015
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DOI: 10.1038/nature14482

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