Parent stem cells can serve as niches for their daughter cells

Ana Pardo-Saganta, Purushothama Rao Tata, Brandon M. Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley and Jayaraj Rajagopal ()
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Ana Pardo-Saganta: Center for Regenerative Medicine, Massachusetts General Hospital
Purushothama Rao Tata: Center for Regenerative Medicine, Massachusetts General Hospital
Brandon M. Law: Center for Regenerative Medicine, Massachusetts General Hospital
Borja Saez: Center for Regenerative Medicine, Massachusetts General Hospital
Ryan Dz-Wei Chow: Center for Regenerative Medicine, Massachusetts General Hospital
Mythili Prabhu: Center for Regenerative Medicine, Massachusetts General Hospital
Thomas Gridley: Center for Molecular Medicine, Maine Medical Center Research Institute
Jayaraj Rajagopal: Center for Regenerative Medicine, Massachusetts General Hospital

Nature, 2015, vol. 523, issue 7562, 597-601

Abstract: Little is known about how the relative proportions of stem cells and differentiated cells are regulated; basal stem/progenitor cells of the mouse airway epithelium self renew and differentiate into secretory and ciliated cells, and basal stem cells continuously send daughter cells a forward niche signal necessary for daughter cell fate maintenance.

Date: 2015
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DOI: 10.1038/nature14553

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