Lanosterol reverses protein aggregation in cataracts

Ling Zhao, Xiang-Jun Chen, Jie Zhu, Yi-Bo Xi, Xu Yang, Li-Dan Hu, Hong Ouyang, Sherrina H. Patel, Xin Jin, Danni Lin, Frances Wu, Ken Flagg, Huimin Cai, Gen Li, Guiqun Cao, Ying Lin, Daniel Chen, Cindy Wen, Christopher Chung, Yandong Wang, Austin Qiu, Emily Yeh, Wenqiu Wang, Xun Hu, Seanna Grob, Ruben Abagyan, Zhiguang Su, Harry Christianto Tjondro, Xi-Juan Zhao, Hongrong Luo, Rui Hou, J. Jefferson, P. Perry, Weiwei Gao, Igor Kozak, David Granet, Yingrui Li, Xiaodong Sun, Jun Wang, Liangfang Zhang (), Yizhi Liu (), Yong-Bin Yan () and Kang Zhang ()
Additional contact information
Ling Zhao: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Xiang-Jun Chen: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University
Jie Zhu: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Yi-Bo Xi: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University
Xu Yang: BGI-Shenzhen
Li-Dan Hu: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University
Hong Ouyang: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Sherrina H. Patel: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Xin Jin: BGI-Shenzhen
Danni Lin: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Frances Wu: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Ken Flagg: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Huimin Cai: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Gen Li: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Guiqun Cao: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Ying Lin: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Daniel Chen: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Cindy Wen: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Christopher Chung: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Yandong Wang: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Austin Qiu: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Emily Yeh: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Wenqiu Wang: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Xun Hu: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Seanna Grob: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Ruben Abagyan: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Zhiguang Su: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Harry Christianto Tjondro: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University
Xi-Juan Zhao: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University
Hongrong Luo: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Rui Hou: Guangzhou KangRui Biological Pharmaceutical Technology Company
P. Perry: University of California Riverside
Weiwei Gao: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Igor Kozak: King Khaled Eye Specialist Hospital
David Granet: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Yingrui Li: BGI-Shenzhen
Xiaodong Sun: Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University
Jun Wang: BGI-Shenzhen
Liangfang Zhang: Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
Yizhi Liu: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Yong-Bin Yan: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University
Kang Zhang: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University

Nature, 2015, vol. 523, issue 7562, 607-611

Abstract: Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which can reduce cataract severity and increase lens transparency in vivo in dogs.

Date: 2015
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DOI: 10.1038/nature14650

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