A hemi-fission intermediate links two mechanistically distinct stages of membrane fission

Juha-Pekka Mattila, Anna V. Shnyrova, Anna C. Sundborger, Eva Rodriguez Hortelano, Marc Fuhrmans, Sylvia Neumann, Marcus Müller, Jenny E. Hinshaw (), Sandra L. Schmid () and Vadim A. Frolov ()
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Juha-Pekka Mattila: UT Southwestern Medical Center
Anna V. Shnyrova: Biophysics Unit (CSIC, University of The Basque Country
Anna C. Sundborger: Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Eva Rodriguez Hortelano: Biophysics Unit (CSIC, University of The Basque Country
Marc Fuhrmans: Institute for Theoretical Physics, Georg-August University
Sylvia Neumann: The Scripps Research Institute
Marcus Müller: Institute for Theoretical Physics, Georg-August University
Jenny E. Hinshaw: Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Sandra L. Schmid: UT Southwestern Medical Center
Vadim A. Frolov: Biophysics Unit (CSIC, University of The Basque Country

Nature, 2015, vol. 524, issue 7563, 109-113

Abstract: The GTPase dynamin provides the driving force for fission of membrane-bound vesicular structures; here, it is shown that dynamin-driven membrane fission proceeds in two mechanistically distinct stages that are separated by a metastable hemi-fission intermediate that requires GTP hydrolysis for progression to full fission.

Date: 2015
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DOI: 10.1038/nature14509

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