Conversion of amides to esters by the nickel-catalysed activation of amide C–N bonds

Liana Hie, Noah F. Fine Nathel, Tejas K. Shah, Emma L. Baker, Xin Hong, Yun-Fang Yang, Peng Liu, K. N. Houk () and Neil K. Garg ()
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Liana Hie: University of California
Noah F. Fine Nathel: University of California
Tejas K. Shah: University of California
Emma L. Baker: University of California
Xin Hong: University of California
Yun-Fang Yang: University of California
Peng Liu: University of California
K. N. Houk: University of California
Neil K. Garg: University of California

Nature, 2015, vol. 524, issue 7563, 79-83

Abstract: Although enzymes are able to cleave amide bonds in nature, it is difficult to selectively break the carbon–nitrogen bond of an amide using synthetic chemistry; now the activation and cleavage of these bonds using nickel catalysts is used to convert amides to esters.

Date: 2015
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DOI: 10.1038/nature14615

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