Protein synthesis by ribosomes with tethered subunits

Cédric Orelle, Erik D. Carlson, Teresa Szal, Tanja Florin, Michael C. Jewett () and Alexander S. Mankin ()
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Cédric Orelle: Center for Pharmaceutical Biotechnology – m/c 870, University of Illinois at Chicago
Erik D. Carlson: Northwestern University
Teresa Szal: Center for Pharmaceutical Biotechnology – m/c 870, University of Illinois at Chicago
Tanja Florin: Center for Pharmaceutical Biotechnology – m/c 870, University of Illinois at Chicago
Michael C. Jewett: Northwestern University
Alexander S. Mankin: Center for Pharmaceutical Biotechnology – m/c 870, University of Illinois at Chicago

Nature, 2015, vol. 524, issue 7563, 119-124

Abstract: A ribosome with tethered subunits, ‘Ribo-T’, is engineered by making a hybrid RNA composed of ribosomal RNA of large and small subunits; Ribo-T can support cell growth in vivo in the absence of wild-type ribosomes, and is used to establish a fully orthogonal ribosome–mRNA system.

Date: 2015
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DOI: 10.1038/nature14862

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