X-ray structure of a mammalian stearoyl-CoA desaturase

Yonghong Bai, Jason G. McCoy, Elena J. Levin, Pablo Sobrado, Kanagalaghatta R. Rajashankar, Brian G. Fox () and Ming Zhou ()
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Yonghong Bai: Baylor College of Medicine
Jason G. McCoy: Baylor College of Medicine
Elena J. Levin: Baylor College of Medicine
Pablo Sobrado: University of Wisconsin–Madison
Kanagalaghatta R. Rajashankar: Cornell University, Argonne National Laboratory
Brian G. Fox: University of Wisconsin–Madison
Ming Zhou: Baylor College of Medicine

Nature, 2015, vol. 524, issue 7564, 252-256

Abstract: The crystal structure of mouse SCD1 bound to fatty acid stearoyl-CoA is solved at 2.6 Å resolution; the structure reveals a novel geometry for the dimetal centre, and the acyl chain of the bound fatty acid is shown to be shielded and shaped to a particular conformation by the enzyme, providing a structural basis for the selectivity of fatty acid metabolism.

Date: 2015
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DOI: 10.1038/nature14549

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