The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

Jinbo Han, Erwei Li, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng and Yiguo Wang ()
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Jinbo Han: MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Erwei Li: MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Liqun Chen: MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Yuanyuan Zhang: MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Fangchao Wei: MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Jieyuan Liu: Proteomics Facility, School of Life Sciences, Tsinghua University
Haiteng Deng: Proteomics Facility, School of Life Sciences, Tsinghua University
Yiguo Wang: MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University

Nature, 2015, vol. 524, issue 7564, 243-246

Abstract: Studies in mice reveal that CREB regulated transcription coactivator 2 (CRTC2) acts as a mediator of mTOR signalling in the liver to regulate SREBP1-controlled lipid homeostasis during feeding and diabetes; overexpression of a CRTC2 mutant defective for mTOR regulation improves the lipogenic program and insulin sensitivity in obese mice.

Date: 2015
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DOI: 10.1038/nature14557

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