Genetic compensation induced by deleterious mutations but not gene knockdowns

Andrea Rossi, Zacharias Kontarakis, Claudia Gerri, Hendrik Nolte, Soraya Hölper, Marcus Krüger and Didier Y. R. Stainier ()
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Andrea Rossi: Max Planck Institute for Heart and Lung Research
Zacharias Kontarakis: Max Planck Institute for Heart and Lung Research
Claudia Gerri: Max Planck Institute for Heart and Lung Research
Hendrik Nolte: Max Planck Institute for Heart and Lung Research
Soraya Hölper: Max Planck Institute for Heart and Lung Research
Marcus Krüger: Max Planck Institute for Heart and Lung Research
Didier Y. R. Stainier: Max Planck Institute for Heart and Lung Research

Nature, 2015, vol. 524, issue 7564, 230-233

Abstract: Zebrafish embryos injected with egfl7 morpholino exhibit severe vascular defects but egfl7 mutants do not show any obvious phenotypes, illustrating the power of comparing mutants and morphants to identify modifier genes.

Date: 2015
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DOI: 10.1038/nature14580

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