Dosage delivery of sensitive reagents enables glove-box-free synthesis

Aaron C. Sather, Hong Geun Lee, James R. Colombe, Anni Zhang and Stephen L. Buchwald ()
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Aaron C. Sather: Massachusetts Institute of Technology
Hong Geun Lee: Massachusetts Institute of Technology
James R. Colombe: Massachusetts Institute of Technology
Anni Zhang: Massachusetts Institute of Technology
Stephen L. Buchwald: Massachusetts Institute of Technology

Nature, 2015, vol. 524, issue 7564, 208-211

Abstract: A method of supplying exactly the amounts of air- and moisture-sensitive catalysts and ligands needed for three commonly used syntheses in a stable, storable form in a sealed capsule is described; it should reduce the unnecessary waste of chemicals, money and time.

Date: 2015
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DOI: 10.1038/nature14654

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