Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

Nadinath B. Nillegoda (), Janine Kirstein, Anna Szlachcic, Mykhaylo Berynskyy, Antonia Stank, Florian Stengel, Kristin Arnsburg, Xuechao Gao, Annika Scior, Ruedi Aebersold, D. Lys Guilbride, Rebecca C. Wade, Richard I. Morimoto, Matthias P. Mayer and Bernd Bukau ()
Additional contact information
Nadinath B. Nillegoda: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
Janine Kirstein: Leibniz-Institute for Molecular Pharmacology (FMP)
Anna Szlachcic: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
Mykhaylo Berynskyy: Heidelberg Institute for Theoretical Studies (HITS)
Antonia Stank: Heidelberg Institute for Theoretical Studies (HITS)
Florian Stengel: Institute of Molecular Systems Biology, ETH Zurich
Kristin Arnsburg: Leibniz-Institute for Molecular Pharmacology (FMP)
Xuechao Gao: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
Annika Scior: Leibniz-Institute for Molecular Pharmacology (FMP)
Ruedi Aebersold: Institute of Molecular Systems Biology, ETH Zurich
D. Lys Guilbride: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
Rebecca C. Wade: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
Richard I. Morimoto: Rice Institute for Biomedical Research, Northwestern University
Matthias P. Mayer: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
Bernd Bukau: Center for Molecular Biology of the University of Heidelberg (ZMBH), German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance

Nature, 2015, vol. 524, issue 7564, 247-251

Abstract: An efficient protein disaggregation system uncovered in metazoan cells requires transient interactions between J-protein co-chaperones of classes A and B, which synergistically boost HSP70-dependent disaggregation activity, providing a flexible further level of regulation for metazoan protein quality control, with direct relevance to human diseases such as age-related neurodegeneration.

Date: 2015
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DOI: 10.1038/nature14884

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