Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

Rushika M. Perera, Svetlana Stoykova, Brandon N. Nicolay, Kenneth N. Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K. Selig, Cristina R. Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J. Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas and Nabeel Bardeesy ()
Additional contact information
Rushika M. Perera: Center for Cancer Research, Massachusetts General Hospital
Svetlana Stoykova: Center for Cancer Research, Massachusetts General Hospital
Brandon N. Nicolay: Center for Cancer Research, Massachusetts General Hospital
Kenneth N. Ross: Center for Cancer Research, Massachusetts General Hospital
Julien Fitamant: Center for Cancer Research, Massachusetts General Hospital
Myriam Boukhali: Center for Cancer Research, Massachusetts General Hospital
Justine Lengrand: Center for Cancer Research, Massachusetts General Hospital
Vikram Deshpande: Harvard Medical School
Martin K. Selig: Massachusetts General Hospital
Cristina R. Ferrone: Center for Cancer Research, Massachusetts General Hospital
Jeff Settleman: Center for Cancer Research, Massachusetts General Hospital
Gregory Stephanopoulos: Massachusetts Institute of Technology
Nicholas J. Dyson: Center for Cancer Research, Massachusetts General Hospital
Roberto Zoncu: University of California at Berkeley
Sridhar Ramaswamy: Center for Cancer Research, Massachusetts General Hospital
Wilhelm Haas: Center for Cancer Research, Massachusetts General Hospital
Nabeel Bardeesy: Center for Cancer Research, Massachusetts General Hospital

Nature, 2015, vol. 524, issue 7565, 361-365

Abstract: The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.

Date: 2015
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DOI: 10.1038/nature14587

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