The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia

Lan Zhao (), Eduardo Oliver, Klio Maratou, Santosh S. Atanur, Olivier D. Dubois, Emanuele Cotroneo, Chien-Nien Chen, Lei Wang, Cristina Arce, Pauline L. Chabosseau, Joan Ponsa-Cobas, Maria G. Frid, Benjamin Moyon, Zoe Webster, Almaz Aldashev, Jorge Ferrer, Guy A. Rutter, Kurt R. Stenmark, Timothy J. Aitman and Martin R. Wilkins
Additional contact information
Lan Zhao: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Eduardo Oliver: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Klio Maratou: Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
Santosh S. Atanur: Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
Olivier D. Dubois: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Emanuele Cotroneo: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Chien-Nien Chen: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Lei Wang: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Cristina Arce: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital
Pauline L. Chabosseau: Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
Joan Ponsa-Cobas: Section of Epigenomics and Disease, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Maria G. Frid: University of Colorado Denver
Benjamin Moyon: Transgenics and Embryonic Stem Cell Laboratory, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
Zoe Webster: Transgenics and Embryonic Stem Cell Laboratory, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
Almaz Aldashev: Institute of Molecular Biology and Medicine
Jorge Ferrer: Section of Epigenomics and Disease, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Guy A. Rutter: Section of Cell Biology and Functional Genomics, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital
Kurt R. Stenmark: University of Colorado Denver
Timothy J. Aitman: Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
Martin R. Wilkins: Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital

Nature, 2015, vol. 524, issue 7565, 356-360

Abstract: Zinc transporter ZIP12 expression is increased in many cell types in remodelled mammalian pulmonary arterioles in hypoxia-induced pulmonary hypertension.

Date: 2015
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DOI: 10.1038/nature14620

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