Mechanism of phospho-ubiquitin-induced PARKIN activation

Tobias Wauer, Michal Simicek, Alexander Schubert and David Komander ()
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Tobias Wauer: Medical Research Council Laboratory of Molecular Biology
Michal Simicek: Medical Research Council Laboratory of Molecular Biology
Alexander Schubert: Medical Research Council Laboratory of Molecular Biology
David Komander: Medical Research Council Laboratory of Molecular Biology

Nature, 2015, vol. 524, issue 7565, 370-374

Abstract: This study provides insights into conformational changes that lead to phospho-ubiquitin-induced PARKIN activation and how PARKIN is recruited to phospho-ubiquitin chains on mitochondria; the crystal structure of PARKIN in complex with phospho-ubiquitin also indicates that the pocket within PARKIN where phospho-ubiquitin binds carries amino acid residues that are mutated in patients with autosomal-recessive juvenile Parkinsonism.

Date: 2015
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DOI: 10.1038/nature14879

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