Conformational dynamics of a class C G-protein-coupled receptor

Reza Vafabakhsh, Joshua Levitz and Ehud Y. Isacoff ()
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Reza Vafabakhsh: University of California
Joshua Levitz: University of California
Ehud Y. Isacoff: University of California

Nature, 2015, vol. 524, issue 7566, 497-501

Abstract: smFRET is used to probe the activation mechanism of two full-length mammalian glutamate receptors, revealing that the extracellular ligand-binding domains of these G-protein-coupled receptors interconvert between three confirmations (resting, activated and a short-lived intermediate state), and that the efficacy of an orthosteric agonist correlates with the degree of occupancy of the active state.

Date: 2015
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DOI: 10.1038/nature14679

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