Sidekick 2 directs formation of a retinal circuit that detects differential motion

Arjun Krishnaswamy, Masahito Yamagata, Xin Duan, Y. Kate Hong and Joshua R. Sanes ()
Additional contact information
Arjun Krishnaswamy: Harvard University
Masahito Yamagata: Harvard University
Xin Duan: Harvard University
Y. Kate Hong: Harvard University
Joshua R. Sanes: Harvard University

Nature, 2015, vol. 524, issue 7566, 466-470

Abstract: The mouse retinal ganglion cell type known as the W3B-RGC, which detects motion of objects against a moving background, is shown to receive strong specific and excitatory input from amacrine cells expressing vesicular glutamine transporter 3; this selective connection is mediated by homophilic interactions of the recognition molecule sidekick 2 (Sdk2), which is expressed on both cells, and disruption of this connection affects object motion detection in W3B-RGCs.

Date: 2015
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DOI: 10.1038/nature14682

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