A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

Xiaowen Wang and Xin Jie Chen ()
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Xiaowen Wang: State University of New York Upstate Medical University
Xin Jie Chen: State University of New York Upstate Medical University

Nature, 2015, vol. 524, issue 7566, 481-484

Abstract: A new pathway of mitochondria-mediated cell death termed mitochondrial precursor over-accumulation stress (mPOS) is identified that could explain the link between mitochondrial dysfunction and misfolding of cytosolic proteins during ageing and disease; the pathway is triggered not only by mutations affecting the core protein import machineries, but also by conditions that interfere with mitochondrial inner membrane integrity and function, and a large network of genes that suppress mPOS in favour of cell survival is also identified.

Date: 2015
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DOI: 10.1038/nature14859

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