Structural basis for stop codon recognition in eukaryotes

Alan Brown, Sichen Shao, Jason Murray, Ramanujan S. Hegde () and V. Ramakrishnan ()
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Alan Brown: MRC Laboratory of Molecular Biology
Sichen Shao: MRC Laboratory of Molecular Biology
Jason Murray: MRC Laboratory of Molecular Biology
Ramanujan S. Hegde: MRC Laboratory of Molecular Biology
V. Ramakrishnan: MRC Laboratory of Molecular Biology

Nature, 2015, vol. 524, issue 7566, 493-496

Abstract: All eukaryotes utilize a single termination factor, eRF1, to halt translation when the ribosome encounters one of three possible stop codons; here electron cryo-microscopy structures of ribosome–eRF1 complexes in the process of recognizing each stop codon reveal how stop codons are discriminated from sense codons.

Date: 2015
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DOI: 10.1038/nature14896

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