SEC14L2 enables pan-genotype HCV replication in cell culture

Mohsan Saeed, Ursula Andreo, Hyo-Young Chung, Christine Espiritu, Andrea D. Branch, Jose M. Silva and Charles M. Rice ()
Additional contact information
Mohsan Saeed: Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University
Ursula Andreo: Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University
Hyo-Young Chung: Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University
Christine Espiritu: Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University
Andrea D. Branch: Icahn School of Medicine at Mount Sinai
Jose M. Silva: Icahn School of Medicine at Mount Sinai
Charles M. Rice: Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University

Nature, 2015, vol. 524, issue 7566, 471-475

Abstract: Hepatitis C virus cannot replicate in cell culture unless it possesses adaptive mutations; here, expression of cellular factor SEC14L2 is shown to allow replication of diverse hepatitis C virus genotypes in several hepatoma cell lines by enhancing vitamin E-mediated protection against lipid peroxidation.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature14899 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:524:y:2015:i:7566:d:10.1038_nature14899

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14899

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().