Regulation of mitochondrial morphology and function by stearoylation of TFR1

Deniz Senyilmaz, Sam Virtue, Xiaojun Xu, Chong Yew Tan, Julian L. Griffin, Aubry K. Miller, Antonio Vidal-Puig and Aurelio A. Teleman ()
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Deniz Senyilmaz: German Cancer Research Center (DKFZ)
Sam Virtue: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
Xiaojun Xu: German Cancer Research Center (DKFZ)
Chong Yew Tan: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
Julian L. Griffin: The Department of Biochemistry
Aubry K. Miller: German Cancer Research Center (DKFZ)
Antonio Vidal-Puig: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
Aurelio A. Teleman: German Cancer Research Center (DKFZ)

Nature, 2015, vol. 525, issue 7567, 124-128

Abstract: Mitochondria have essential functions within cells, and their dysfunction is linked to various disorders; here, the fatty acid stearic acid (C18:0), which is a dietary component, and the transferrin receptor (TFR1) are shown to regulate mitochondrial function.

Date: 2015
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DOI: 10.1038/nature14601

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