Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity

Alexandra Van Keymeulen (), May Yin Lee, Marielle Ousset, Sylvain Brohée, Sandrine Rorive, Rajshekhar R. Giraddi, Aline Wuidart, Gaëlle Bouvencourt, Christine Dubois, Isabelle Salmon, Christos Sotiriou, Wayne A. Phillips and Cédric Blanpain ()
Additional contact information
Alexandra Van Keymeulen: Université Libre de Bruxelles
May Yin Lee: Université Libre de Bruxelles
Marielle Ousset: Université Libre de Bruxelles
Sylvain Brohée: Institut Jules Bordet, Université Libre de Bruxelles
Sandrine Rorive: Erasme Hospital, Université Libre de Bruxelles
Rajshekhar R. Giraddi: Université Libre de Bruxelles
Aline Wuidart: Université Libre de Bruxelles
Gaëlle Bouvencourt: Université Libre de Bruxelles
Christine Dubois: Université Libre de Bruxelles
Isabelle Salmon: Erasme Hospital, Université Libre de Bruxelles
Christos Sotiriou: Institut Jules Bordet, Université Libre de Bruxelles
Wayne A. Phillips: Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre
Cédric Blanpain: Université Libre de Bruxelles

Nature, 2015, vol. 525, issue 7567, 119-123

Abstract: PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, PIK3CA mutations are shown to activate a genetic program directing multiple cell fates in normally lineage-restricted cell types.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature14665 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:525:y:2015:i:7567:d:10.1038_nature14665

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14665

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().