PIK3CAH1047R induces multipotency and multi-lineage mammary tumours

Shany Koren, Linsey Reavie, Joana Pinto Couto, Duvini De Silva, Michael B. Stadler, Tim Roloff, Adrian Britschgi, Tobias Eichlisberger, Hubertus Kohler, Olulanu Aina, Robert D. Cardiff and Mohamed Bentires-Alj ()
Additional contact information
Shany Koren: Friedrich Miescher Institute for Biomedical Research (FMI)
Linsey Reavie: Friedrich Miescher Institute for Biomedical Research (FMI)
Joana Pinto Couto: Friedrich Miescher Institute for Biomedical Research (FMI)
Duvini De Silva: Friedrich Miescher Institute for Biomedical Research (FMI)
Michael B. Stadler: Friedrich Miescher Institute for Biomedical Research (FMI)
Tim Roloff: Friedrich Miescher Institute for Biomedical Research (FMI)
Adrian Britschgi: Friedrich Miescher Institute for Biomedical Research (FMI)
Tobias Eichlisberger: Friedrich Miescher Institute for Biomedical Research (FMI)
Hubertus Kohler: Friedrich Miescher Institute for Biomedical Research (FMI)
Olulanu Aina: Center for Comparative Medicine, University of California Davis
Robert D. Cardiff: Center for Comparative Medicine, University of California Davis
Mohamed Bentires-Alj: Friedrich Miescher Institute for Biomedical Research (FMI)

Nature, 2015, vol. 525, issue 7567, 114-118

Abstract: PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, the PIK3CAH1047R mutation is shown to induce multipotent stem-like cells and mammary tumours with different levels of malignancy depending on the cell of origin.

Date: 2015
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DOI: 10.1038/nature14669

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