Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

Junchao Dong, Rohit A. Panchakshari, Tingting Zhang, Yu Zhang, Jiazhi Hu, Sabrina A. Volpi, Robin M. Meyers, Yu-Jui Ho, Zhou Du, Davide F. Robbiani, Feilong Meng, Monica Gostissa, Michel C. Nussenzweig, John P. Manis () and Frederick W. Alt ()
Additional contact information
Junchao Dong: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Rohit A. Panchakshari: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Tingting Zhang: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Yu Zhang: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Jiazhi Hu: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Sabrina A. Volpi: Boston Children’s Hospital and Joint Program in Transfusion Medicine, Harvard Medical School
Robin M. Meyers: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Yu-Jui Ho: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Zhou Du: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Davide F. Robbiani: Howard Hughes Medical Institute, Laboratory of Molecular Immunology, The Rockefeller University
Feilong Meng: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Monica Gostissa: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Michel C. Nussenzweig: Howard Hughes Medical Institute, Laboratory of Molecular Immunology, The Rockefeller University
John P. Manis: Boston Children’s Hospital and Joint Program in Transfusion Medicine, Harvard Medical School
Frederick W. Alt: Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School

Nature, 2015, vol. 525, issue 7567, 134-139

Abstract: High-throughput genome-wide sequencing reveals why class switch recombination in the IgH locus, an essential step in the process of antibody generation, has a directional joining bias towards deletion rather than inversion.

Date: 2015
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DOI: 10.1038/nature14970

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