Computational design of co-assembling protein–DNA nanowires

Yun Mou (), Jiun-Yann Yu, Timothy M. Wannier, Chin-Lin Guo and Stephen L. Mayo ()
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Yun Mou: California Institute of Technology
Jiun-Yann Yu: California Institute of Technology
Timothy M. Wannier: California Institute of Technology
Chin-Lin Guo: California Institute of Technology
Stephen L. Mayo: California Institute of Technology

Nature, 2015, vol. 525, issue 7568, 230-233

Abstract: Computational protein design is used to create a protein–DNA co-assembling nanomaterial; by varying the arrangement of protein-binding sites on the double-stranded DNA, a ‘nanowire’ with single-molecule width can be spontaneously formed by mixing the protein and double-stranded DNA building blocks.

Date: 2015
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DOI: 10.1038/nature14874

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